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Persistent sad, anxious or “empty” mood
Sleeping too much or too little, middle of the night or early morning waking
Reduced appetite and weight loss, or increased appetite and weight gain
Loss of pleasure and interest in activities once enjoyed, including sex
Restlessness, irritability
Persistent physical symptoms that do not respond to treatment (such as chronic pain or digestive disorders)
Difficulty concentrating, remembering or making decisions
Fatigue or loss of energy
Feeling guilty, hopeless or worthless
Thoughts of suicide or death