Symptoms

Persistent sad, anxious or “empty” mood Sleeping too much or too little, middle of the night or early morning waking Reduced appetite and weight loss, or increased appetite and weight gain Loss of pleasure and interest in activities once enjoyed, including sex Restlessness, irritability Persistent physical symptoms that do not respond to treatment (such as chronic pain or digestive disorders) Difficulty concentrating, remembering or making decisions Fatigue or loss of energy Feeling guilty, hopeless or worthless Thoughts of suicide or death